Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.48 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | VCP | P55072 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29711979 | 0.85 | TDP1 (0.48) | TDP1ATMMAPTALDH1A1HIF1A | |
| SCHEMBL660797 | 0.85 | TDP1 (0.48) | TDP1ATMMAPTALDH1A1HIF1A | |
| SCHEMBL632916 | 0.85 | MAPT (0.56) | TDP1ATMMAPTALDH1A1HIF1A | |
| SCHEMBL29793298 | 0.85 | MAPT (0.56) | TDP1ATMMAPTALDH1A1HIF1A | |
| SCHEMBL34460054 | 0.82 | ALDH1A1 (0.47) | TDP1ATMMAPTALDH1A1HIF1A | |
| SCHEMBL22833410 | 0.82 | CYP1A2 (0.52) | TDP1ATMMAPTALDH1A1HIF1A | |
| SCHEMBL3345953 | 0.82 | ALDH1A1 (0.47) | TDP1ATMMAPTALDH1A1HIF1A | |
| SCHEMBL10835047 | 0.82 | GPR35 (0.50) | TDP1ATMMAPTALDH1A1HIF1A | |
| SCHEMBL33527983 | 0.82 | TDP1 (0.50) | TDP1ATMMAPTALDH1A1HIF1A | |
| SCHEMBL29069638 | 0.82 | TDP1 (0.52) | TDP1ATMMAPTALDH1A1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268422-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | Bayer Aktiengesellschaft (DE) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070687-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-09-27 | — | — | WO | disclosed |