Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.46 |
| ▸ | PIN4 | Q9Y237 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9323818 | 0.84 | KMT2A (0.76) | KMT2AMEN1ATMPTPN1MAPT | |
| SCHEMBL9322607 | 0.82 | KMT2A (0.76) | KMT2AMEN1ATMPTPN1MAPT | |
| SCHEMBL9324908 | 0.82 | KMT2A (0.72) | KMT2AMEN1ATMPTPN1MAPT | |
| SCHEMBL6968780 | 0.82 | KMT2A (0.55) | KMT2AMAPTALDH1A1 | |
| SCHEMBL9323443 | 0.81 | KMT2A (0.68) | KMT2AMEN1ATMPTPN1MAPT | |
| SCHEMBL9324924 | 0.81 | KMT2A (0.67) | KMT2AMEN1ATMPTPN1PIN1 | |
| SCHEMBL9322643 | 0.81 | KMT2A (0.78) | KMT2AMEN1ATMPTPN1MAPT | |
| SCHEMBL9325709 | 0.81 | KMT2A (0.67) | KMT2AMEN1ATMMAPTALDH1A1 | |
| SCHEMBL9323487 | 0.80 | KMT2A (0.65) | KMT2AMEN1ATMPTPN1MAPT | |
| SCHEMBL9323639 | 0.80 | KMT2A (0.65) | KMT2AMEN1ATMPTPN1PIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0718289-B1 | Novel parabanic acid derivatives as aldose reductase inhibitors | NIPPON ZOKI PHARMACEUTICAL CO (JP) | 2003-03-05 | — | — | EP | disclosed |
| US-5681843-A | ANTIDIABETIC; ALDOSE REDUCTASE INHIBITOR WITHOUT SUBSTANTIALLY INHIBITING ALDEHYDE REDUCATASE | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1997-10-28 | — | — | US | disclosed |
| EP-0718289-A1 | Novel parabanic acid derivatives as aldose reductase inhibitors | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1996-06-26 | — | — | EP | disclosed |