Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.76 |
| ▸ | CMA1 | P23946 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | ATM | Q13315 | 2/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8149590 | 0.85 | CMA1 (0.69) | KMT2ACMA1MEN1ATMALDH1A1 | |
| SCHEMBL9322643 | 0.84 | KMT2A (0.78) | KMT2AMEN1ATMPTPN1ALDH1A1 | |
| SCHEMBL8873641 | 0.84 | KMT2A (0.73) | KMT2AMEN1ATMPTPN1MAPT | |
| SCHEMBL9323818 | 0.83 | KMT2A (0.76) | KMT2AMEN1ATMPTPN1ALDH1A1 | |
| SCHEMBL9322747 | 0.83 | KMT2A (0.71) | KMT2AMEN1ATMPTPN1ALDH1A1 | |
| SCHEMBL8872446 | 0.82 | KMT2A (0.74) | KMT2AMEN1ATMPTPN1ALDH1A1 | |
| SCHEMBL6978776 | 0.82 | KMT2A (0.70) | KMT2AMEN1ATMPTPN1ALDH1A1 | |
| SCHEMBL9325709 | 0.82 | KMT2A (0.67) | KMT2AMEN1ATMALDH1A1MAPT | |
| SCHEMBL8871853 | 0.81 | KMT2A (0.73) | KMT2AMEN1ATMPTPN1ALDH1A1 | |
| SCHEMBL9324908 | 0.78 | KMT2A (0.72) | KMT2AMEN1ATMPTPN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0353198-B1 | Parabanic acid derivatives and pharmaceutical compositions containing them | NIPPON ZOKI PHARMACEUTICAL CO (JP) | 1994-02-02 | — | — | EP | disclosed |
| US-4985453-A | DIABETES TREATMENT | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1991-01-15 | — | — | US | disclosed |
| EP-0353198-A1 | Parabanic acid derivatives and pharmaceutical compositions containing them | NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) | 1990-01-31 | — | — | EP | disclosed |