Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | CKS1B | P61024 | 1/20 | 0.44 |
| ▸ | SKP1 | P63208 | 1/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.44 |
| ▸ | FNTA | P49354 | 1/20 | 0.44 |
| ▸ | FNTB | P49356 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6971773 | 0.88 | GPR119 (0.56) | GPR119HPGDRECQLMAP4K4CKS1B | |
| SCHEMBL3486495 | 0.87 | GPR119 (0.72) | GPR119MAP4K4 | |
| SCHEMBL6982726 | 0.85 | GPR119 (0.55) | GPR119HPGDRECQLMAP4K4CKS1B | |
| SCHEMBL6981587 | 0.84 | GPR119 (0.59) | GPR119HPGDRECQLCKS1BSKP1 | |
| SCHEMBL6977687 | 0.83 | GPR119 (0.57) | GPR119HPGDRECQLCKS1BSKP1 | |
| Hydrochloric Acid SCHEMBL6978099 | 0.79 | CHRNB2 (0.48) | MAP4K4CHRM4KMT2AGBA1 | |
| SCHEMBL6181184 | 0.79 | GPR119 (0.76) | GPR119HPGDRECQLMAP4K4CKS1B | |
| Hydrochloric Acid SCHEMBL6983696 | 0.78 | GBA1 (0.50) | CKS1BSKP1SKP2CHRM4KMT2A | |
| SCHEMBL29132224 | 0.78 | GPR119 (0.53) | GPR119HPGDRECQLCKS1BSKP1 | |
| SCHEMBL7165667 | 0.76 | GPR119 (0.71) | GPR119HPGDRECQLCKS1BSKP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925286-B1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ASTRAZENECA AB (SE) | 2003-01-02 | — | — | EP | disclosed |
| US-6093718-A | AN OXIDO-SQUALENE CYCLASE INHIBITOR, ANTICHOLESTEROL AGENT FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND LOWERING CHOLESTEROL LEVELS IN BLOOD PLASMA; TREATING HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2000-07-25 | — | — | US | disclosed |
| CN-1228087-A | Substituted pyrimidine derivatives and their pharmaceutical use | ZENECA LTD (GB) | 1999-09-08 | — | — | CN | disclosed |
| EP-0925286-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ZENECA LIMITED (GB) | 1999-06-30 | — | — | EP | disclosed |
| WO-1998006705-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ZENECA LIMITED (GB) | 1998-02-19 | — | — | WO | disclosed |