Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25281534 | 0.77 | POLB (0.54) | HSD17B10HPGDPOLBKMT2AMEN1 | |
| SCHEMBL6980965 | 0.75 | POLB (0.60) | POLBLTA4H | |
| SCHEMBL6975490 | 0.73 | KMT2A (0.41) | HPGDPOLBKMT2AMEN1ALOX15 | |
| SCHEMBL9520411 | 0.73 | POLB (0.49) | HSD17B10POLBLTA4H | |
| SCHEMBL5364784 | 0.70 | KMT2A (0.50) | HSD17B10HPGDPOLBKMT2AMEN1 | |
| SCHEMBL6977732 | 0.70 | HSD17B10 (0.40) | HSD17B10HPGDPOLBKMT2AMEN1 | |
| SCHEMBL10722024 | 0.69 | HPGD (0.51) | HSD17B10HPGDPOLBKMT2AMEN1 | |
| SCHEMBL2375467 | 0.69 | HPGD (0.51) | HSD17B10HPGDPOLBKMT2AMEN1 | |
| SCHEMBL6978974 | 0.68 | HSD17B10 (0.38) | HSD17B10HPGDPOLBCYP3A4KMT2A | |
| SCHEMBL6968878 | 0.68 | HSD17B10 (0.48) | HSD17B10HPGDPOLBCYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821674-B1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2003-08-06 | — | — | EP | claimed |