Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6980965 | 0.75 | POLB (0.60) | POLB | |
| SCHEMBL6978978 | 0.73 | HSD17B10 (0.38) | KMT2AMEN1MAPTALOX15HPGD | |
| SCHEMBL5863707 | 0.73 | USP2 (0.46) | KMT2AMEN1HTTGAAUSP2 | |
| SCHEMBL6976712 | 0.70 | USP2 (0.43) | KMT2AMEN1HTTGAAUSP2 | |
| SCHEMBL8522199 | 0.69 | USP2 (0.56) | KMT2AMEN1HTTGAAUSP2 | |
| SCHEMBL2511016 | 0.68 | KMT2A (0.44) | KMT2AMEN1HTTGAAALDH1A1 | |
| SCHEMBL6973085 | 0.68 | USP2 (0.41) | KMT2AMEN1HTTGAAUSP2 | |
| SCHEMBL6975487 | 0.68 | USP2 (0.41) | KMT2AMEN1HTTGAAUSP2 | |
| SCHEMBL10923368 | 0.67 | LMNA (0.42) | KMT2AMEN1HTTGAAUSP2 | |
| SCHEMBL13278218 | 0.67 | USP2 (0.50) | KMT2AMEN1USP2CHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821674-B1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2003-08-06 | — | — | EP | claimed |