Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 2/20 | 0.44 |
| ▸ | FNTB | P49356 | 2/20 | 0.44 |
| ▸ | FDPS | P14324 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | USP1 | O94782 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL693477 | 0.86 | FNTA (0.47) | FNTAFNTBFDPSKMT2AMEN1 | |
| Bromide SCHEMBL28813244 | 0.85 | FNTA (0.46) | FNTAFNTBFDPSKMT2AMEN1 | |
| SCHEMBL6977430 | 0.84 | FDPS (0.40) | FNTAFNTBFDPSKMT2AMEN1 | |
| SCHEMBL12530334 | 0.83 | FDPS (0.44) | FNTAFNTBFDPSKMT2AMEN1 | |
| SCHEMBL7677314 | 0.81 | FPR2 (0.38) | FNTAFNTBFDPSKMT2AMEN1 | |
| SCHEMBL26488892 | 0.80 | FNTA (0.48) | FNTAFNTBFDPSKMT2AMEN1 | |
| SCHEMBL17082712 | 0.80 | FNTA (0.47) | FNTAFNTBFDPSKMT2AMEN1 | |
| SCHEMBL2490033 | 0.79 | FDPS (0.43) | FNTAFNTBFDPSKMT2AMEN1 | |
| SCHEMBL5541391 | 0.79 | FNTA (0.47) | FNTAFNTBFDPSKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL28457259 | 0.79 | FNTA (0.47) | FNTAFNTBFDPSKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1106615-B1 | Substituted 1,4-dihydropyridine compounds as bradykinin antagonists | PFIZER (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-1106615-A1 | Substituted 1,4-dihydropyridine compounds as bradykinin antagonists | PFIZER INC. (US) | 2001-06-13 | — | — | EP | disclosed |