Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.38 |
| ▸ | LTA4H | P09960 | 3/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6975450 | 0.93 | PPARG (0.41) | PPARGPPARDPPARAPSEN1LTA4H | |
| SCHEMBL6977672 | 0.88 | PPARG (0.40) | PPARGPPARDPPARAPSEN1LTA4H | |
| SCHEMBL7085291 | 0.84 | MAPT (0.37) | PPARGPPARDPPARAPSEN1ALOX5 | |
| SCHEMBL6968782 | 0.83 | PPARG (0.39) | PPARGPPARDPPARAPSEN1LTA4H | |
| SCHEMBL6979922 | 0.83 | MEN1 (0.42) | PPARGPSEN1ALOX5MEN1KMT2A | |
| SCHEMBL6970202 | 0.83 | KCNH2 (0.45) | PPARGPPARDPPARAPSEN1MEN1 | |
| SCHEMBL6968604 | 0.81 | PPARG (0.46) | PPARGPPARAMEN1KMT2AMAPT | |
| SCHEMBL6976223 | 0.79 | PPARG (0.37) | PPARGPPARDPPARALTA4HALOX5 | |
| SCHEMBL8484423 | 0.79 | PSEN1 (0.42) | PPARGPPARDPPARAPSEN1ALOX5 | |
| SCHEMBL6979341 | 0.79 | PSEN1 (0.42) | PPARGPPARDPPARAPSEN1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0801063-B1 | Thiazolidinedione derivatives having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | REDDYS LAB LTD DR (IN) | 2003-01-15 | — | — | EP | disclosed |
| EP-0801063-A1 | Thiazolidinedione derivatives having antidiabetic, hypolipidaemic antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | DR. REDDY'S RESEARCH FOUNDATION (IN) | 1997-10-15 | — | — | EP | disclosed |