Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | TTPA | P49638 | 3/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 8/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6975450 | 0.90 | PPARG (0.41) | MEN1KMT2APPARGALOX5MAPT | |
| SCHEMBL6968213 | 0.84 | MEN1 (0.47) | MEN1KMT2APDE4APDE3APPARG | |
| SCHEMBL6979165 | 0.83 | PPARG (0.40) | MEN1KMT2APDE4APDE3APPARG | |
| SCHEMBL6978127 | 0.82 | TTPA (0.47) | MEN1KMT2APDE4APDE3ATTPA | |
| SCHEMBL6977672 | 0.81 | PPARG (0.40) | MEN1KMT2APPARGALOX5MAPT | |
| SCHEMBL10635760 | 0.80 | MEN1 (0.50) | MEN1KMT2APDE4APDE3APPARG | |
| SCHEMBL7454938 | 0.78 | PPARG (0.49) | MEN1KMT2APDE4APDE3APPARG | |
| SCHEMBL8484326 | 0.76 | MEN1 (0.56) | MEN1KMT2APDE4APDE3ATTPA | |
| SCHEMBL6977122 | 0.74 | MEN1 (0.54) | MEN1KMT2APDE4APDE3ATTPA | |
| SCHEMBL10638935 | 0.72 | PPARG (0.54) | MEN1KMT2APDE4APDE3APPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0801063-B1 | Thiazolidinedione derivatives having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | REDDYS LAB LTD DR (IN) | 2003-01-15 | — | — | EP | disclosed |
| EP-0801063-A1 | Thiazolidinedione derivatives having antidiabetic, hypolipidaemic antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | DR. REDDY'S RESEARCH FOUNDATION (IN) | 1997-10-15 | — | — | EP | disclosed |