Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 5/20 | 0.41 |
| ▸ | CNR1 | P21554 | 3/20 | 0.41 |
| ▸ | ACHE | P22303 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6970142 | 0.90 | CNR2 (0.54) | CNR2CNR1ACHEMAPTLMNA | |
| SCHEMBL6978209 | 0.84 | CNR1 (0.49) | CNR2CNR1ACHEMAPTRXFP1 | |
| SCHEMBL6968667 | 0.78 | HTR6 (0.48) | MAPTPOLBAKR1C3AKR1C2LMNA | |
| SCHEMBL6975193 | 0.78 | CNR2 (0.51) | CNR2CNR1ACHEMAPTLMNA | |
| SCHEMBL6979571 | 0.78 | CNR2 (0.56) | CNR2CNR1ACHEMAPTPOLB | |
| SCHEMBL6970702 | 0.78 | HTR6 (0.47) | MAPTPOLBAKR1C3AKR1C2LMNA | |
| SCHEMBL6977942 | 0.75 | CNR2 (0.44) | CNR2CNR1ACHEMAPTPOLB | |
| SCHEMBL6975027 | 0.75 | HTR6 (0.45) | MAPTAKR1C3AKR1C2TP53 | |
| SCHEMBL6974448 | 0.74 | CNR1 (0.48) | CNR2CNR1ACHEPOLBNPSR1 | |
| SCHEMBL6966090 | 0.74 | HTR6 (0.44) | AKR1C3AKR1C2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077947-B1 | NOVEL 1,5 AND 3-O-SUBSTITUTED 1H-INDAZOLES WITH ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY, IMMUNO-MODULATING AND NEURO-PROTECTIVE EFFECT, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | DRESDEN ARZNEIMITTEL (DE) | 2003-09-03 | — | — | EP | claimed |