SCHEMBL6979345

SCHEMBL6979345

COc1ccc(NC(N)=S)cc1.N#C[Na]

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.58
HPGD P15428 3/20 0.58
CYP2C19 P33261 2/20 0.58
CYP3A4 P08684 1/20 0.58
CYP2D6 P10635 1/20 0.58
CYP2C9 P11712 1/20 0.58
ALOX12 P18054 1/20 0.58
CYP1A2 P05177 1/20 0.51
MAOA P21397 2/20 0.50
MAOB P27338 2/20 0.50
SMN1; SMN2 Q16637 5/20 0.49
NPC1 O15118 3/20 0.49
RAB9A P51151 3/20 0.49
MAPT P10636 3/20 0.47
GAA P10253 3/20 0.47
KMT2A Q03164 2/20 0.47
MEN1 O00255 1/20 0.47
HTT P42858 1/20 0.47
LMNA P02545 1/20 0.46
TDP1 Q9NUW8 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL526026 0.89 ALDH1A1 (0.70) ALDH1A1HPGDCYP2C19CYP3A4CYP2D6
SCHEMBL20536958 0.84 ALDH1A1 (0.81) ALDH1A1HPGDCYP2C19CYP3A4CYP2D6
SCHEMBL6983302 0.81 ALDH1A1 (0.50) ALDH1A1HPGDCYP2C19CYP3A4CYP2D6
SCHEMBL6982143 0.77 MAPT (0.52) ALDH1A1HPGDCYP2C19CYP3A4CYP2D6
SCHEMBL9725063 0.77 HPGD (0.61) ALDH1A1HPGDCYP2C19CYP3A4CYP2D6
SCHEMBL9382061 0.76 KMT2A (0.66) ALDH1A1CYP3A4CYP2C9SMN1; SMN2NPC1
SCHEMBL6978792 0.76 ALDH1A1 (0.61) ALDH1A1ALOX12MAOAMAOBMAPT
SCHEMBL13715007 0.76 HPGD (0.66) ALDH1A1HPGDCYP2C19CYP3A4CYP2C9
SCHEMBL8983529 0.75 HPGD (0.64) ALDH1A1HPGDCYP2C19CYP1A2MAOA
SCHEMBL12904023 0.74 PPIA (0.70) ALDH1A1ALOX12SMN1; SMN2MAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1228058-A4 BENZOPYRANYL GUANIDINE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM DONGBU HANNONG CHEMICAL CO LTD (KR) 2003-02-12 EP disclosed
EP-1228058-A1 BENZOPYRANYL GUANIDINE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Dongbu Hannong Chemical Co., Ltd. (KR) 2002-08-07 EP disclosed
WO-2001029023-A1 BENZOPYRANYL GUANIDINE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2001-04-26 WO disclosed