Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | CCR3 | P51677 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6984356 | 0.94 | SMN1; SMN2 (0.53) | NAMPTTP53SMN1; SMN2MAPTNPC1 | |
| SCHEMBL7085009 | 0.89 | TP53 (0.49) | NAMPTTP53SMN1; SMN2MAPTHDAC1 | |
| Hydrochloric Acid SCHEMBL6986749 | 0.87 | SMN1; SMN2 (0.46) | TP53SMN1; SMN2MAPTTSHRNPC1 | |
| SCHEMBL6977738 | 0.87 | TP53 (0.51) | TP53SMN1; SMN2MAPTTSHRNPC1 | |
| SCHEMBL7964635 | 0.84 | TP53 (0.47) | TP53SMN1; SMN2TSHRHDAC1HDAC8 | |
| SCHEMBL6977395 | 0.84 | TP53 (0.46) | TP53SMN1; SMN2MAPTTSHRNPC1 | |
| SCHEMBL6981022 | 0.83 | TP53 (0.51) | TP53HDAC1HDAC8HDAC6 | |
| SCHEMBL6980215 | 0.83 | TP53 (0.42) | NAMPTTP53SMN1; SMN2MAPTNPC1 | |
| SCHEMBL7409209 | 0.82 | IDO1 (0.60) | TP53SMN1; SMN2MAPTHDAC1HDAC8 | |
| SCHEMBL6984354 | 0.82 | PTGER4 (0.49) | NAMPTTP53MAPTTSHRHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0991624-B1 | PHENYLALKYL DERIVATIVES WITH THROMBIN-INHIBITING EFFECT | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-11-19 | — | — | EP | disclosed |
| US-6300342-B1 | FOR THERAPY OR INHIBITING THROMBUS FORMATION; FOR THERAPY OF FIBRIN-DEPENDENT INFLAMMATORY CONDITION | BOEHRINGER INGELHEIM PHARM KG (DE) | 2001-10-09 | — | — | US | disclosed |