SCHEMBL6981022

SCHEMBL6981022

N#Cc1ccc(CCC(=O)N2CCCc3cc(C(=O)NCc4ccccc4-c4ccccc4)ccc32)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 2/20 0.51
DRD2 P14416 6/20 0.44
DRD3 P35462 4/20 0.44
IDO1 P14902 3/20 0.43
KCNH2 Q12809 3/20 0.43
DRD4 P21917 2/20 0.41
DRD1 P21728 1/20 0.41
DRD5 P21918 1/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC8 Q9BY41 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
USP30 Q70CQ3 1/20 0.41
HTR1A P08908 1/20 0.40
HTR2A P28223 1/20 0.40
HTR7 P34969 1/20 0.40
HTR5A P47898 1/20 0.40
HTR6 P50406 1/20 0.40
THRB P10828 2/20 0.40
POLB P06746 1/20 0.40
CHRM3 P20309 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6984356 0.86 SMN1; SMN2 (0.53) TP53HDAC1HDAC8HDAC6
SCHEMBL6977738 0.84 TP53 (0.51) TP53IDO1KCNH2HDAC1HDAC8
SCHEMBL6979412 0.83 NAMPT (0.49) TP53HDAC1HDAC8HDAC6
SCHEMBL7409209 0.83 IDO1 (0.60) TP53IDO1KCNH2HDAC1HDAC8
SCHEMBL7085009 0.83 TP53 (0.49) TP53IDO1KCNH2HDAC1HDAC8
SCHEMBL7964635 0.81 TP53 (0.47) TP53IDO1KCNH2HDAC1HDAC8
SCHEMBL6977395 0.81 TP53 (0.46) TP53HDAC1HDAC8HDAC6
SCHEMBL18414292 0.80 HDAC1 (0.52) TP53DRD2DRD3DRD4DRD1
SCHEMBL6984354 0.79 PTGER4 (0.49) TP53IDO1KCNH2HDAC1HDAC8
SCHEMBL6979174 0.79 TP53 (0.50) TP53IDO1KCNH2HDAC1HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0991624-B1 PHENYLALKYL DERIVATIVES WITH THROMBIN-INHIBITING EFFECT BOEHRINGER INGELHEIM PHARMA (DE) 2003-11-19 EP disclosed
US-6300342-B1 FOR THERAPY OR INHIBITING THROMBUS FORMATION; FOR THERAPY OF FIBRIN-DEPENDENT INFLAMMATORY CONDITION BOEHRINGER INGELHEIM PHARM KG (DE) 2001-10-09 US disclosed
EP-0991624-A1 PHENYLALKYL DERIVATIVES WITH THROMBIN-INHIBITING EFFECT Boehringer Ingelheim Pharma KG (DE) 2000-04-12 EP disclosed
WO-1999000371-A1 PHENYLALKYL DERIVATIVES WITH THROMBIN-INHIBITING EFFECT BOEHRINGER INGELHEIM PHARMA KG (DE) 1999-01-07 WO disclosed