Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | PDE7A | Q13946 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | NPY1R | P25929 | 1/20 | 0.51 |
| ▸ | NPY2R | P49146 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22854483 | 0.88 | ALDH1A1 (0.53) | KCNH2HRH3SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL16346178 | 0.88 | ALDH1A1 (0.53) | KCNH2HRH3SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL10163613 | 0.88 | ALDH1A1 (0.53) | KCNH2HRH3SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL22854519 | 0.88 | ALDH1A1 (0.53) | KCNH2HRH3CYP1A2CYP2C9SMN1; SMN2 | |
| SCHEMBL10163671 | 0.88 | ALDH1A1 (0.53) | KCNH2HRH3SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL22854760 | 0.88 | ALDH1A1 (0.53) | KCNH2HRH3CYP1A2CYP2C9SMN1; SMN2 | |
| SCHEMBL22854518 | 0.88 | ALDH1A1 (0.53) | KCNH2HRH3CYP1A2CYP2C9SMN1; SMN2 | |
| SCHEMBL451131 | 0.85 | NPC1 (0.52) | KCNH2HRH3ALDH1A1TSHRPDE7A | |
| SCHEMBL20061286 | 0.84 | POLB (0.54) | KCNH2HRH3CYP1A2CYP2C9SMN1; SMN2 | |
| SCHEMBL19576287 | 0.83 | PIK3CD (0.57) | KCNH2HRH3CYP1A2CYP2C9SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183276-B2 | Therapeutic agents | MERCK SHARP & DOHME CORP. | 2012-05-22 | — | — | US | disclosed |
| US-20100324029-A1 | THERAPEUTIC AGENTS | MERCK SHARP & DOHME CORP. | 2010-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324029-A1 | THERAPEUTIC AGENTS | PSEN2, PSEN1, BACE2 | KCNH2 3290/4885HRH3 1144/4885CYP1A2 2032/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.