Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | PDE7A | Q13946 | 3/20 | 0.52 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | NPY1R | P25929 | 1/20 | 0.49 |
| ▸ | NPY2R | P49146 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL448044 | 0.92 | SMN1; SMN2 (0.60) | ALDH1A1RAB9ASMN1; SMN2LMNAMAPK1 | |
| SCHEMBL450719 | 0.90 | PTGS2 (0.51) | ALDH1A1TSHRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL451255 | 0.88 | ALDH1A1 (0.64) | ALDH1A1TSHRRAB9ASMN1; SMN2LMNA | |
| SCHEMBL10163613 | 0.88 | ALDH1A1 (0.53) | ALDH1A1TSHRPDE7APDE7BNPC1 | |
| SCHEMBL10163671 | 0.88 | ALDH1A1 (0.53) | ALDH1A1TSHRPDE7APDE7BNPC1 | |
| SCHEMBL6979418 | 0.88 | KCNH2 (0.59) | ALDH1A1TSHRPDE7APDE7BNPC1 | |
| SCHEMBL22854760 | 0.85 | ALDH1A1 (0.53) | ALDH1A1TSHRPDE7APDE7BNPC1 | |
| SCHEMBL22854518 | 0.85 | ALDH1A1 (0.53) | ALDH1A1TSHRPDE7APDE7BNPC1 | |
| SCHEMBL22854483 | 0.85 | ALDH1A1 (0.53) | ALDH1A1TSHRPDE7APDE7BNPC1 | |
| SCHEMBL22854519 | 0.85 | ALDH1A1 (0.53) | ALDH1A1TSHRPDE7APDE7BNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11352359-B2 | PI3K protein kinase inhibitors | RHIZEN PHARMACEUTICALS AG (CH) | 2022-06-07 | — | — | US | disclosed |
| US-11352359-B2 | PI3K protein kinase inhibitors | RHIZEN PHARMACEUTICALS AG (CH) | 2022-06-07 | — | — | US | disclosed |
| CN-111153905-A | PI3K protein kinase inhibitors, in particular delta inhibitors and/or gamma inhibitors | 理森制药股份公司 | 2020-05-15 | — | — | CN | disclosed |
| CN-105431437-B | PI3K protein kinase inhibitors, in particular delta inhibitors and/or gamma inhibitors | 理森制药股份公司 | 2020-03-10 | — | — | CN | disclosed |
| EP-3016955-B1 | PI3K PROTEIN KINASE INHIBITORS, PARTICULARLY DELTA AND/OR GAMMA INHIBITORS | RHIZEN PHARMACEUTICALS S A (CH) | 2018-03-07 | — | — | EP | disclosed |
| US-20160207929-A1 | PI3K PROTEIN KINASE INHIBITORS, PARTICULARLY DELTA AND/OR GAMMA INHIBITORS | RHIZEN PHARMACEUTICALS SA (CH) | 2016-07-21 | — | — | US | disclosed |
| US-20160207929-A1 | PI3K PROTEIN KINASE INHIBITORS, PARTICULARLY DELTA AND/OR GAMMA INHIBITORS | RHIZEN PHARMACEUTICALS SA (CH) | 2016-07-21 | — | — | US | disclosed |
| US-20160207929-A1 | PI3K PROTEIN KINASE INHIBITORS, PARTICULARLY DELTA AND/OR GAMMA INHIBITORS | RHIZEN PHARMACEUTICALS SA (CH) | 2016-07-21 | — | — | US | disclosed |
| EP-3016955-A1 | PI3K PROTEIN KINASE INHIBITORS, PARTICULARLY DELTA AND/OR GAMMA INHIBITORS | Rhizen Pharmaceuticals S.A. (CH) | 2016-05-11 | — | — | EP | disclosed |
| WO-2015001491-A1 | PI3K PROTEIN KINASE INHIBITORS, PARTICULARLY DELTA AND/OR GAMMA INHIBITORS | RHIZEN PHARMACEUTICALS SA (CH) | 2015-01-08 | — | — | WO | disclosed |
| WO-2015001491-A1 | PI3K PROTEIN KINASE INHIBITORS, PARTICULARLY DELTA AND/OR GAMMA INHIBITORS | RHIZEN PHARMACEUTICALS SA (CH) | 2015-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11352359-B2 | PI3K protein kinase inhibitors | PIK3CD, PIK3R5, PIK3CB | ALDH1A1 4545/4885TSHR 3554/4885PDE7A 843/4885 |
| US-20160207929-A1 | PI3K PROTEIN KINASE INHIBITORS, PARTICULARLY DELTA AND/OR GAMMA INHIBITORS | PRKCZ, PRKCE, PRKCA | ALDH1A1 4486/4885TSHR 3192/4885PDE7A 816/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.