Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Valproic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.94 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.94 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.94 |
| ▸ | HTR2A | P28223 | 1/20 | 0.94 |
| ▸ | HTR2C | P28335 | 1/20 | 0.94 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.94 |
| ▸ | HRH1 | P35367 | 1/20 | 0.94 |
| ▸ | DRD3 | P35462 | 1/20 | 0.94 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.94 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.94 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.94 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.94 |
| ▸ | SLC1A2 | P43004 | 4/20 | 0.60 |
| ▸ | SLC1A1 | P43005 | 4/20 | 0.60 |
| ▸ | GRIK1 | P39086 | 4/20 | 0.60 |
| ▸ | GRIK2 | Q13002 | 4/20 | 0.60 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Valproic Acid SCHEMBL1000802 | 0.97 | CHRM1 (0.89) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL1330837 | 0.97 | CHRM1 (1.00) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL140241 | 0.97 | CHRM1 (1.00) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL2275 | 0.97 | CHRM1 (1.00) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL6910916 | 0.94 | CHRM1 (0.94) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL7579608 | 0.94 | CHRM1 (0.94) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL139238 | 0.94 | CHRM1 (0.94) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| SCHEMBL1738242 | 0.94 | CHRM1 (0.94) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL2054191 | 0.94 | CHRM1 (0.94) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL21378840 | 0.94 | CHRM1 (0.94) | CHRM1AKR1A1CHRM3HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 531 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-121577789-A | Method for detecting 2-propyl-4-pentenoic acid in anti-epileptic drug valproic acid | 湖南省湘中制药有限公司 | 2026-02-27 | — | — | CN | claimed |
| EP-3445343-B1 | COMPOSITION AND METHOD FOR PRETREATING CANCER | VALCURIA AB (SE) | 2026-02-25 | — | — | EP | claimed |
| US-20250302781-A1 | METHOD FOR PRETREATING RELAPSING CANCER | VALCURIA AB (SE) | 2025-10-02 | — | — | US | claimed |
| CN-119793529-A | Mediating agent and preparation method and application thereof | 中环齐锐技发科技(成都)有限公司 | 2025-04-11 | — | — | CN | claimed |
| EP-4529457-A1 | METHOD FOR PRETREATING RELAPSING CANCER | Valcuria AB (SE) | 2025-04-02 | — | — | EP | claimed |
| EP-4512393-A1 | COMBINATION OF SODIUM DICHLOROACETATE AND VALPROIC ACID SALTS FOR THE TREATMENT OF VIRAL AND BACTERIAL INFECTIONS AND INFLAMMATORY DISEASES | Lietuvos Sveikatos Mokslu Universitetas (LT) | 2025-02-26 | — | — | EP | claimed |
| WO-2025003475-A1 | COMPOSITION AND METHOD FOR PRETREATING CANCER | VALCURIA AB (SE) | 2025-01-02 | — | — | WO | claimed |
| EP-4483864-A1 | COMPOSITION AND METHOD FOR PRETREATING CANCER | Valcuria AB (SE) | 2025-01-01 | — | — | EP | claimed |
| CN-116621732-B | 2-Cyano-2-valproate and preparation method and application thereof | 湖南大学 | 2024-12-24 | — | — | CN | claimed |
| US-12059502-B2 | Composition and method for pretreating cancer | VALCURIA AB (SE) | 2024-08-13 | — | — | US | claimed |
| CN-1732974-A | Medicinal composition of fructose diphosphate sodium and magnesium salt | YANG XIHONG (CN) | 2006-02-15 | — | — | CN | claimed |
| CN-1729988-A | Composite medicine of creatine phosphate sodium and magnesium salt | YANG XIHONG (CN) | 2006-02-08 | — | — | CN | claimed |
| US-20050186288-A1 | Compositions and methods for the prophylaxis and treatment of aphthous ulcers and herpes simplex lesions | CHIOU CONSULTING INC. (US) | 2005-08-25 | — | — | US | claimed |
| CN-1141090-C | Magnesium valproate sustained-release tablet and preparation process thereof | 湖南省湘中制药有限公司 | 2004-03-10 | — | — | CN | claimed |
| CN-1302607-A | Magnesium valproate sustained-release tablet and preparation process thereof | XIANGZHONG PHARMACEUTICAL CO L (CN) | 2001-07-11 | — | — | CN | claimed |
| EP-0637449-B1 | Use of L-carnitine or acyl L-carnitines and valproate for treating seizure disorders | SIGMA TAU IND FARMACEUTI (IT) | 1998-01-07 | — | — | EP | claimed |
| EP-0637449-A1 | Use of L-carnitine or acyl L-carnitines and valproate for treating seizure disorders | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1995-02-08 | — | — | EP | claimed |
| EP-0433848-B1 | Crystalline magnesium valproate and a method for the preparation thereof | SIGMA TAU IND FARMACEUTI (IT) | 1994-06-22 | — | — | EP | claimed |
| US-5180850-A | Salt formation by reaction of valproic acid and magnesium alkoxide in alcohol solvent | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 1993-01-19 | — | — | US | claimed |
| EP-0433848-A1 | Crystalline magnesium valproate and a method for the preparation thereof | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1991-06-26 | — | — | EP | claimed |