Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 8/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8483767 | 0.88 | PSEN1 (0.40) | PSEN1ALOX5MEN1KMT2AMAPT | |
| SCHEMBL6980211 | 0.88 | PSEN1 (0.38) | PSEN1ALOX5MEN1KMT2AMAPT | |
| SCHEMBL6969686 | 0.88 | PSEN1 (0.40) | PSEN1ALOX5MEN1KMT2AMAPT | |
| SCHEMBL6975335 | 0.83 | KCNH2 (0.39) | PSEN1ALOX5MEN1KMT2AMAPT | |
| SCHEMBL6967404 | 0.82 | PSEN1 (0.37) | PSEN1ALOX5MEN1KMT2AMAPT | |
| SCHEMBL6976820 | 0.81 | CYP1A2 (0.40) | PSEN1ALOX5MEN1KMT2AMAPT | |
| SCHEMBL8486214 | 0.81 | PSEN1 (0.39) | PSEN1ALOX5MEN1KMT2AMAPT | |
| SCHEMBL29670864 | 0.81 | PSEN1 (0.44) | PSEN1ALOX5MEN1KMT2AMAPT | |
| SCHEMBL7839568 | 0.81 | PSEN1 (0.42) | PSEN1ALOX5MEN1KMT2AMAPT | |
| SCHEMBL11440558 | 0.81 | PSEN1 (0.44) | PSEN1ALOX5MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0801063-B1 | Thiazolidinedione derivatives having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | REDDYS LAB LTD DR (IN) | 2003-01-15 | — | — | EP | disclosed |
| US-5925656-A | CONTAINING A 2,4-DIOXOTRIAZOLIDINE RING | DR. REDDY'S RESEARCH FOUNDATION (IN) | 1999-07-20 | — | — | US | disclosed |
| EP-0801063-A1 | Thiazolidinedione derivatives having antidiabetic, hypolipidaemic antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | DR. REDDY'S RESEARCH FOUNDATION (IN) | 1997-10-15 | — | — | EP | disclosed |