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SCHEMBL6979563

SCHEMBL6979563

CC(C)OC(CC(C(OC(C)C)S(=O)(=O)Cc1cnc2ccccc2c1)N(C=O)OC(C)(C)C)C(CSCc1cnc2ccccc2c1)N(C=O)OC(C)(C)C

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ HIF1A Q16665 1/20 0.31
▸ EPAS1 Q99814 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6985930 0.82 — —
SCHEMBL6404016 0.82 — —
SCHEMBL6078553 0.79 PDE10A (0.35) HIF1AEPAS1
SCHEMBL6404687 0.78 MMP2 (0.30) —
SCHEMBL6404185 0.77 HIF1A (0.31) HIF1AEPAS1
SCHEMBL6990550 0.77 HIF1A (0.38) HIF1AEPAS1
SCHEMBL6753401 0.76 — —
SCHEMBL6608514 0.76 PDE10A (0.37) HIF1AEPAS1
SCHEMBL6661883 0.75 PDE10A (0.35) HIF1AEPAS1
SCHEMBL6605020 0.74 PDE10A (0.33) HIF1AEPAS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1289980-A1 BICYCLYL OR HETEROBICYCLYLMETHANESULFONYLAMINO-SUBSTITUTED N-HYDROXYFORMAMIDES SMITHKLINE BEECHAM PLC (GB) 2003-03-12 — — EP disclosed
WO-2001090100-A1 BICYCLYL OR HETEROBICYCLYLMETHANESULFONYLAMINO-SUBSTITUTED N-HYDROXYFORMAMIDES SMITHKLINE BEECHAM P.L.C. (GB) 2001-11-29 — — WO disclosed