Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OXTR | P30559 | 2/20 | 0.51 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | F12 | P00748 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4942094 | 1.00 | OXTR (0.51) | OXTRAVPR1AHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL4942106 | 1.00 | OXTR (0.51) | OXTRAVPR1AHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL4941821 | 0.91 | ALDH1A1 (0.43) | OXTRAVPR1AHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL4941819 | 0.91 | ALDH1A1 (0.43) | OXTRAVPR1AHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL4944243 | 0.87 | USP2 (0.45) | OXTRHTTALDH1A1SMN1; SMN2POLB | |
| SCHEMBL4944248 | 0.87 | USP2 (0.45) | OXTRHTTALDH1A1SMN1; SMN2POLB | |
| SCHEMBL4936062 | 0.87 | OXTR (0.56) | OXTRAVPR1AAGTR2 | |
| SCHEMBL4936068 | 0.87 | OXTR (0.56) | OXTRAVPR1AAGTR2 | |
| SCHEMBL4942668 | 0.83 | POLB (0.45) | OXTRAVPR1AHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL4942686 | 0.83 | POLB (0.45) | OXTRAVPR1AHTTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268419-A1 | PYRROLIDINE DERIVATIVES USEFUL AS BAX INHIBITORS | Applied Research Systems ARS Holding N.V. (AN) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001072705-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-10-04 | — | — | WO | disclosed |