Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6160228 | 0.80 | CYP1A2 (0.33) | KDM4EKMT2A | |
| SCHEMBL6946153 | 0.74 | CYP1A2 (0.33) | KDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL7815578 | 0.71 | MEN1 (0.55) | KDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL15322148 | 0.71 | SMN1; SMN2 (0.38) | POLBGAASMN1; SMN2 | |
| SCHEMBL8301176 | 0.69 | HTT (0.36) | KMT2A | |
| SCHEMBL6175645 | 0.68 | HSD11B1 (0.38) | KDM4EKMT2APOLBGAASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4611963 | 0.67 | HSD11B1 (0.37) | KDM4EKMT2AGAASMN1; SMN2 | |
| SCHEMBL27661416 | 0.67 | SMN1; SMN2 (0.37) | KDM4EKMT2APOLBGAASMN1; SMN2 | |
| SCHEMBL6158571 | 0.65 | PPIA (0.35) | — | |
| SCHEMBL13208084 | 0.64 | POLB (0.39) | KMT2APOLBGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119355-B1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2003-01-08 | — | — | EP | disclosed |
| US-6500818-B1 | Naphthalenecarboxamides as tachykinin receptor antagonists | ASTRAZENECA AB (SE) | 2002-12-31 | — | — | US | disclosed |
| EP-1119355-A1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000020003-A1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-04-13 | — | — | WO | disclosed |