Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.62 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.62 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.60 |
| ▸ | SMO | Q99835 | 2/20 | 0.60 |
| ▸ | CSF1R | P07333 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6971304 | 0.93 | BRAF (0.65) | BRAFHSF1MAPK14SMOCSF1R | |
| SCHEMBL6979946 | 0.90 | MAPK14 (0.74) | BRAFHSF1MAPK14SMOCSF1R | |
| SCHEMBL5897251 | 0.88 | BRAF (0.76) | BRAFHSF1MAPK14SMOCSF1R | |
| SCHEMBL1680575 | 0.88 | PABPC1 (0.72) | RAB9ANPC1SMN1; SMN2PABPC1POLB | |
| SCHEMBL1680510 | 0.88 | RAB9A (0.64) | RAB9ANPC1SMN1; SMN2PABPC1POLB | |
| SCHEMBL6975716 | 0.85 | BRAF (0.72) | BRAFHSF1MAPK14SMOCSF1R | |
| SCHEMBL7827201 | 0.84 | MAPK14 (0.65) | BRAFHSF1MAPK14SMOCSF1R | |
| SCHEMBL6979731 | 0.83 | MAPK14 (0.69) | BRAFHSF1MAPK14SMOCSF1R | |
| SCHEMBL5897048 | 0.83 | BRAF (0.71) | BRAFHSF1CSF1RRAB9ANPC1 | |
| SCHEMBL1681165 | 0.83 | NR1H4 (0.62) | RAB9ANPC1SMN1; SMN2PABPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115707-B1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2003-11-12 | — | — | EP | disclosed |
| US-6455520-B1 | TUMOR NECROSIS FACTOR AND INTERLEUKIN INHIBITORS; ANTIINFLAMMATORY AGENTS, ANTIALLERGENS; BONE DISORDERS | ASTRA ZENECA AB (SE) | 2002-09-24 | — | — | US | disclosed |