Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5842416 | 0.99 | MAPT (0.56) | MAPTMEN1KMT2ATSHRNPC1 | |
| SCHEMBL5840364 | 0.95 | MAPT (0.57) | MAPTMEN1KMT2ATSHRMAPK1 | |
| SCHEMBL5841552 | 0.80 | GRIN1 (0.55) | MEN1KMT2AGRIN1GRIN2BALDH1A1 | |
| Hydrochloric Acid SCHEMBL5840866 | 0.79 | GRIN1 (0.54) | MEN1KMT2AGRIN1GRIN2BALDH1A1 | |
| SCHEMBL5842866 | 0.77 | GRIN1 (0.54) | MEN1KMT2AGRIN1GRIN2BALDH1A1 | |
| Hydrochloric Acid SCHEMBL5841279 | 0.76 | GRIN1 (0.53) | MEN1KMT2AGRIN1GRIN2BALDH1A1 | |
| SCHEMBL6978967 | 0.74 | LMNA (0.53) | KMT2ATP53ALDH1A1POLB | |
| SCHEMBL5654699 | 0.73 | KMT2A (0.65) | MAPTMEN1KMT2ATSHRNPC1 | |
| Hydrochloric Acid SCHEMBL5842876 | 0.73 | KMT2A (0.55) | MAPTMEN1KMT2ATSHRTP53 | |
| SCHEMBL5843143 | 0.73 | SIGMAR1 (0.55) | SMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1275647-B1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-11-12 | — | — | EP | disclosed |
| EP-1275647-A1 | Octahydro-2H-pyrido[1,2-a]pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-01-15 | — | — | EP | disclosed |