Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 4/20 | 0.58 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL7117922 | 0.99 | PGR (0.57) | PGRMAPK8MAPK9POLBSMN1; SMN2 | |
| SCHEMBL6978729 | 0.77 | PGR (0.59) | PGRMAPK8MAPK9POLBSMN1; SMN2 | |
| SCHEMBL7651124 | 0.74 | PGR (0.68) | PGRMAPK8MAPK9POLBSMN1; SMN2 | |
| SCHEMBL6975699 | 0.72 | PGR (0.59) | PGRMAPK8MAPK9POLBSMN1; SMN2 | |
| SCHEMBL6980685 | 0.72 | PGR (0.56) | PGRMAPK8MAPK9POLBSMN1; SMN2 | |
| SCHEMBL22201345 | 0.71 | PGR (0.72) | PGRMAPK8MAPK9POLBSMN1; SMN2 | |
| SCHEMBL6967657 | 0.71 | PGR (0.57) | PGRMAPK8MAPK9POLBSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7124568 | 0.70 | PGR (0.56) | PGRMAPK8MAPK9POLBSMN1; SMN2 | |
| SCHEMBL6977516 | 0.70 | PGR (0.58) | PGRSMN1; SMN2KMT2AALDH1A1CYP1A2 | |
| SCHEMBL6980952 | 0.69 | PGR (0.59) | PGRMAPK8MAPK9KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1346992-A1 | Quinazoline derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-09-24 | — | — | EP | disclosed |