Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 4/20 | 0.68 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | FABP4 | P15090 | 1/20 | 0.42 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201345 | 0.78 | PGR (0.72) | PGRMAPK8MAPK9SMN1; SMN2KMT2A | |
| SCHEMBL10760314 | 0.77 | TSHR (0.56) | PGRMAPK1KDM4E | |
| SCHEMBL6977516 | 0.76 | PGR (0.58) | PGRSMN1; SMN2KMT2AMAPK1ALDH1A1 | |
| SCHEMBL8831732 | 0.76 | RORA (0.69) | PGRALDH1A1FABP4FABP5 | |
| SCHEMBL7655121 | 0.76 | NPSR1 (0.58) | SMN1; SMN2KMT2APOLBMEN1ALDH1A1 | |
| SCHEMBL5036947 | 0.75 | TNF (0.62) | PGRMAPK1ALDH1A1KDM4E | |
| SCHEMBL6967657 | 0.75 | PGR (0.57) | PGRMAPK8MAPK9SMN1; SMN2KMT2A | |
| SCHEMBL351619 | 0.75 | FABP4 (0.58) | FABP4FABP5 | |
| SCHEMBL30479089 | 0.75 | FABP4 (0.58) | FABP4FABP5 | |
| SCHEMBL22201332 | 0.75 | PGR (0.64) | PGRMAPK8MAPK9SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |