Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTRB1 | P17538 | 2/20 | 0.50 |
| ▸ | DPP4 | P27487 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | REN | P00797 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL697985 | 1.00 | CTRB1 (0.50) | CTRB1DPP4ALDH1A1TRPM8ALOX15 | |
| SCHEMBL344346 | 0.90 | CTRB1 (0.53) | CTRB1DPP4SYKCASP1 | |
| SCHEMBL344345 | 0.90 | CTRB1 (0.53) | CTRB1DPP4SYKCASP1 | |
| SCHEMBL16286390 | 0.89 | SYK (0.53) | CTRB1DPP4TRPM8SYKCTSL | |
| SCHEMBL15604140 | 0.89 | SYK (0.53) | CTRB1DPP4TRPM8SYKCTSL | |
| SCHEMBL19500637 | 0.85 | SYK (0.50) | CTRB1DPP4SYKCTSLCTSB | |
| SCHEMBL28184491 | 0.84 | CTRB1 (0.68) | CTRB1ALDH1A1TRPM8ALOX15SYK | |
| SCHEMBL7280375 | 0.84 | CTRB1 (0.68) | CTRB1ALDH1A1TRPM8ALOX15SYK | |
| SCHEMBL13084120 | 0.84 | DPP4 (0.42) | DPP4ABCB1CYP3A4 | |
| SCHEMBL17227455 | 0.83 | DPP4 (0.44) | DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2423178-A1 | Process for the production of sitagliptin | Chemo Ibérica, S.A. (ES) | 2012-02-29 | — | — | EP | claimed |
| US-9359385-B2 | Preparation of sitagliptin intermediates | LEK PHARMACEUTICALS D.D. (SI) | 2016-06-07 | — | — | US | disclosed |
| US-9359385-B2 | Preparation of sitagliptin intermediates | LEK PHARMACEUTICALS D.D. (SI) | 2016-06-07 | — | — | US | disclosed |
| EP-2714646-B1 | PREPARATION OF SITAGLIPTIN INTERMEDIATES | LEK PHARMACEUTICALS (SI) | 2015-11-04 | — | — | EP | disclosed |
| US-20140187558-A1 | PREPARATION OF SITAGLIPTIN INTERMEDIATES | LEK PHARMACEUTICALS D.D. (SI) | 2014-07-03 | — | — | US | disclosed |
| US-20140187558-A1 | PREPARATION OF SITAGLIPTIN INTERMEDIATES | LEK PHARMACEUTICALS D.D. (SI) | 2014-07-03 | — | — | US | disclosed |
| WO-2012163815-A1 | PREPARATION OF SITAGLIPTIN INTERMEDIATES | LEK PHARMACEUTICALS D.D. (SI) | 2012-12-06 | — | — | WO | disclosed |
| EP-2423178-A1 | Process for the production of sitagliptin | Chemo Ibérica, S.A. (ES) | 2012-02-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140187558-A1 | PREPARATION OF SITAGLIPTIN INTERMEDIATES | DPP4, DPP3, DPP9 | CTRB1 351/4885DPP4 1/4885ALDH1A1 1546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.