Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.74 |
| ▸ | CNR1 | P21554 | 1/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | STS | P08842 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | TGM2 | P21980 | 2/20 | 0.56 |
| ▸ | F13A1 | P00488 | 1/20 | 0.56 |
| ▸ | TGM1 | P22735 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6982617 | 0.93 | GAA (0.65) | GAACNR1NPSR1STSALDH1A1 | |
| SCHEMBL6970591 | 0.89 | GAA (0.72) | GAACNR1NPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7086266 | 0.89 | ALDH1A1 (0.59) | GAAALDH1A1LMNATGM2F13A1 | |
| SCHEMBL5253160 | 0.88 | POLB (0.70) | GAACNR1STSLMNATGM2 | |
| SCHEMBL5736874 | 0.87 | F10 (0.64) | GAACNR1NPSR1STSSMN1; SMN2 | |
| SCHEMBL6980123 | 0.86 | LSS (0.60) | GAACNR1ALDH1A1LMNATGM2 | |
| SCHEMBL6972262 | 0.82 | NPC1 (0.56) | GAAALDH1A1TGM2F13A1TGM1 | |
| SCHEMBL6787216 | 0.80 | KMT2A (0.65) | GAAALDH1A1SMN1; SMN2LMNARAB9A | |
| SCHEMBL14016492 | 0.80 | STS (0.56) | GAACNR1STSTGM2F13A1 | |
| SCHEMBL6974195 | 0.79 | EPHX2 (0.53) | STSTGM2F13A1TGM1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925286-B1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ASTRAZENECA AB (SE) | 2003-01-02 | — | — | EP | disclosed |
| US-6093718-A | AN OXIDO-SQUALENE CYCLASE INHIBITOR, ANTICHOLESTEROL AGENT FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND LOWERING CHOLESTEROL LEVELS IN BLOOD PLASMA; TREATING HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2000-07-25 | — | — | US | disclosed |
| EP-0925286-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ZENECA LIMITED (GB) | 1999-06-30 | — | — | EP | disclosed |
| WO-1998006705-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ZENECA LIMITED (GB) | 1998-02-19 | — | — | WO | disclosed |