Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.53 |
| ▸ | EGFR | P00533 | 6/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.53 |
| ▸ | FLT1 | P17948 | 5/20 | 0.53 |
| ▸ | FLT4 | P35916 | 5/20 | 0.53 |
| ▸ | RET | P07949 | 10/20 | 0.47 |
| ▸ | KIF5B | P33176 | 7/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.45 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.44 |
| ▸ | MERTK | Q12866 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6984858 | 0.88 | KDR (0.45) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL4687801 | 0.80 | RET (0.66) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL4689357 | 0.79 | KDR (0.67) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL4690872 | 0.79 | EGFR (0.58) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL7619208 | 0.76 | KDR (0.44) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL7146877 | 0.75 | SRC (0.65) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL4593476 | 0.75 | ENPP1 (0.59) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL4590452 | 0.75 | ENPP1 (0.59) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL6986140 | 0.75 | KDR (0.48) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL6984111 | 0.75 | FGFR1 (0.43) | KDREGFRFGFR1FLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296973-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AstraZeneca AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002000644-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |