Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.45 |
| ▸ | EGFR | P00533 | 7/20 | 0.45 |
| ▸ | FLT1 | P17948 | 6/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.45 |
| ▸ | FLT4 | P35916 | 5/20 | 0.45 |
| ▸ | EPHA2 | P29317 | 10/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 7/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.42 |
| ▸ | MERTK | Q12866 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6980010 | 0.88 | KDR (0.53) | KDREGFRFLT1FGFR1FLT4 | |
| SCHEMBL7619208 | 0.84 | KDR (0.44) | KDREGFRFLT1FGFR1FLT4 | |
| SCHEMBL4690872 | 0.83 | EGFR (0.58) | KDREGFRFLT1FGFR1FLT4 | |
| SCHEMBL4687659 | 0.81 | SRC (0.58) | KDREGFRFLT1FGFR1FLT4 | |
| SCHEMBL4686372 | 0.80 | EGFR (0.64) | KDREGFRFLT1FGFR1FLT4 | |
| SCHEMBL7135281 | 0.80 | KIT (0.38) | KDREGFRFLT1FGFR1FLT4 | |
| SCHEMBL6984111 | 0.79 | FGFR1 (0.43) | KDREGFRFLT1FGFR1FLT4 | |
| SCHEMBL4689353 | 0.78 | KDR (0.55) | KDREGFRFLT1FGFR1FLT4 | |
| SCHEMBL4686384 | 0.78 | KDR (0.61) | KDREGFRFLT1FGFR1FLT4 | |
| SCHEMBL5828725 | 0.77 | FLT1 (0.62) | KDREGFRFLT1FGFR1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296973-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AstraZeneca AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002000644-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |