Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.54 |
| ▸ | EGFR | P00533 | 8/20 | 0.54 |
| ▸ | RET | P07949 | 2/20 | 0.49 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 2/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.46 |
| ▸ | FLT4 | P35916 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6982367 | 0.94 | EGFR (0.55) | KDREGFRRETEPHA2EPHB4 | |
| SCHEMBL7165079 | 0.91 | KDR (0.59) | KDREGFRRETEPHA2EPHB4 | |
| SCHEMBL5828882 | 0.87 | PDGFRB (0.49) | KDREGFRRETFLT1CSF1R | |
| SCHEMBL5828886 | 0.87 | PDGFRB (0.49) | KDREGFRRETFLT1CSF1R | |
| SCHEMBL6980237 | 0.86 | KDR (0.53) | KDREGFRRETFGFR1FLT1 | |
| SCHEMBL6984966 | 0.85 | EGFR (0.58) | KDREGFRRETEPHA2EPHB4 | |
| SCHEMBL5828140 | 0.81 | EGFR (0.50) | KDREGFRRETPDGFRBAURKA | |
| SCHEMBL5828139 | 0.81 | EGFR (0.50) | KDREGFRRETPDGFRBAURKA | |
| SCHEMBL6985354 | 0.80 | AXL (0.39) | KDREGFREPHA2EPHB4FGFR1 | |
| SCHEMBL6982645 | 0.79 | EGFR (0.59) | KDREGFRRETAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296973-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AstraZeneca AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002000644-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |