Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CASP3 | P42574 | 4/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | MDM4 | O15151 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23525155 | 1.00 | KMT2A (0.53) | KMT2ACASP3EPHX2MDM4TP53 | |
| SCHEMBL29390431 | 1.00 | KMT2A (0.53) | KMT2ACASP3EPHX2MDM4TP53 | |
| SCHEMBL7156981 | 1.00 | KMT2A (0.53) | KMT2ACASP3EPHX2MDM4TP53 | |
| Hydrochloric Acid SCHEMBL1344001 | 0.89 | CASP3 (0.56) | KMT2ACASP3EPHX2MDM4TP53 | |
| Hydrochloric Acid SCHEMBL30428250 | 0.89 | CASP3 (0.56) | KMT2ACASP3EPHX2MDM4TP53 | |
| Hydrochloric Acid SCHEMBL28884223 | 0.89 | CASP3 (0.56) | KMT2ACASP3EPHX2MDM4TP53 | |
| SCHEMBL178736 | 0.88 | CASP3 (0.57) | KMT2ACASP3EPHX2MDM4TP53 | |
| SCHEMBL12681450 | 0.88 | CASP3 (0.56) | KMT2ACASP3EPHX2MDM4TP53 | |
| SCHEMBL16000770 | 0.88 | KMT2A (0.54) | KMT2ACASP3EPHX2MDM4TP53 | |
| SCHEMBL25002346 | 0.88 | CASP3 (0.56) | KMT2ACASP3EPHX2MDM4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |
| EP-1089964-A1 | HYDRAZINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000000465-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-01-06 | — | — | WO | disclosed |