Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 18/20 | 0.50 |
| ▸ | HRH2 | P25021 | 12/20 | 0.50 |
| ▸ | HRH1 | P35367 | 12/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6984761 | 0.84 | HRH2 (0.49) | HRH3HRH2HRH1MMP3 | |
| SCHEMBL6986426 | 0.84 | HRH2 (0.49) | HRH3HRH2HRH1MMP3 | |
| SCHEMBL6987144 | 0.82 | HRH3 (0.49) | HRH3HRH2HRH1MMP3 | |
| SCHEMBL6983118 | 0.80 | HRH3 (0.46) | HRH3HRH2HRH1MMP3 | |
| SCHEMBL6986434 | 0.80 | HRH3 (0.46) | HRH3HRH2HRH1ALDH1A1MMP3 | |
| SCHEMBL7134601 | 0.80 | HRH2 (0.46) | HRH3HRH2HRH1MMP3 | |
| SCHEMBL6985870 | 0.78 | HRH2 (0.47) | HRH3HRH2HRH1 | |
| SCHEMBL6847378 | 0.77 | HRH2 (0.46) | HRH3HRH2HRH1 | |
| SCHEMBL6842225 | 0.76 | HRH2 (0.59) | HRH3HRH2HRH1ALDH1A1 | |
| SCHEMBL6981316 | 0.76 | HRH2 (0.44) | HRH3HRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1301480-A1 | 1,3-DISUBSTITUTED AND 1,3,3-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | ABBOTT LABORATORIES (US) | 2003-04-16 | — | — | EP | claimed |
| WO-2002006223-A1 | 1,3-DISUBSTITUTED AND 1,3,3-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | ABBOTT LABORATORIES (US) | 2002-01-24 | — | — | WO | claimed |