Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 14/20 | 0.46 |
| ▸ | HRH2 | P25021 | 12/20 | 0.46 |
| ▸ | HRH1 | P35367 | 12/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986426 | 0.86 | HRH2 (0.49) | HRH3HRH2HRH1CHRM4MMP3 | |
| SCHEMBL6984761 | 0.83 | HRH2 (0.49) | HRH3HRH2HRH1MMP3HDAC1 | |
| SCHEMBL7134601 | 0.82 | HRH2 (0.46) | HRH3HRH2HRH1CHRM4MMP3 | |
| SCHEMBL6847378 | 0.81 | HRH2 (0.46) | HRH3HRH2HRH1 | |
| SCHEMBL6987144 | 0.81 | HRH3 (0.49) | HRH3HRH2HRH1MMP3HDAC1 | |
| SCHEMBL6980404 | 0.80 | HRH3 (0.50) | HRH3HRH2HRH1ALDH1A1MMP3 | |
| SCHEMBL6983118 | 0.79 | HRH3 (0.46) | HRH3HRH2HRH1MMP3HDAC1 | |
| SCHEMBL6842225 | 0.79 | HRH2 (0.59) | HRH3HRH2HRH1ALDH1A1MAPT | |
| SCHEMBL6985870 | 0.76 | HRH2 (0.47) | HRH3HRH2HRH1 | |
| SCHEMBL6981316 | 0.76 | HRH2 (0.44) | HRH3HRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1301480-A1 | 1,3-DISUBSTITUTED AND 1,3,3-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | ABBOTT LABORATORIES (US) | 2003-04-16 | — | — | EP | claimed |
| WO-2002006223-A1 | 1,3-DISUBSTITUTED AND 1,3,3-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | ABBOTT LABORATORIES (US) | 2002-01-24 | — | — | WO | claimed |