Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 10/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.39 |
| ▸ | REN | P00797 | 2/20 | 0.37 |
| ▸ | MBTPS1 | Q14703 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981910 | 0.87 | REN (0.42) | HRH3SLC6A2SLC6A4KCNH2SLC6A3 | |
| SCHEMBL6981109 | 0.87 | REN (0.42) | SLC6A2SLC6A4KCNH2SLC6A3REN | |
| SCHEMBL6980416 | 0.81 | SLC6A2 (0.43) | HRH3SLC6A2SLC6A4KCNH2HTR2A | |
| SCHEMBL6985983 | 0.77 | F10 (0.43) | SLC6A2SLC6A4KCNH2SLC6A3MBTPS1 | |
| SCHEMBL7140946 | 0.75 | SLC6A2 (0.40) | SLC6A2SLC6A4KCNH2SLC6A3REN | |
| SCHEMBL7143855 | 0.75 | SLC6A2 (0.40) | SLC6A2SLC6A4KCNH2SLC6A3REN | |
| SCHEMBL6983020 | 0.69 | UTS2R (0.45) | SLC6A2SLC6A4KCNH2MBTPS1 | |
| SCHEMBL6981912 | 0.69 | REN (0.44) | HRH3SLC6A2SLC6A4KCNH2SLC6A3 | |
| SCHEMBL6981110 | 0.69 | REN (0.44) | SLC6A2SLC6A4KCNH2SLC6A3REN | |
| SCHEMBL6984730 | 0.69 | UTS2R (0.44) | MBTPS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246619-A4 | UROTENSIN-II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-05-02 | — | — | EP | claimed |
| EP-1246619-A1 | UROTENSIN-II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-09 | — | — | EP | claimed |
| WO-2001045700-A1 | UROTENSIN-II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-06-28 | — | — | WO | claimed |
| EP-1246619-A4 | UROTENSIN-II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-05-02 | — | — | EP | disclosed |
| EP-1246619-A1 | UROTENSIN-II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001045700-A1 | UROTENSIN-II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-06-28 | — | — | WO | disclosed |