SCHEMBL698045

SCHEMBL698045

c1ccc2c(c1)Oc1ccccc1-n1cncc1-2

nearest known ligand 0.41

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
GPBAR1 Q8TDU6 2/20 0.41
HSP90AA1 P07900 2/20 0.40
HSP90AB1 P08238 2/20 0.40
P2RX4 Q99571 6/20 0.39
GABRG2 P18507 2/20 0.38
GABRB3 P28472 2/20 0.38
GABRA5 P31644 2/20 0.38
IDO1 P14902 3/20 0.37
CYP1A2 P05177 1/20 0.35
CYP2D6 P10635 1/20 0.35
KDM4E B2RXH2 1/20 0.33
MAPK1 P28482 1/20 0.33
ATM Q13315 1/20 0.33
MAPT P10636 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
SETD7 Q8WTS6 1/20 0.32
TDO2 P48775 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17651970 0.70 GPBAR1 (0.41) GPBAR1HSP90AA1HSP90AB1GABRG2GABRB3
SCHEMBL23586118 0.70 GPBAR1 (0.41) GPBAR1HSP90AA1HSP90AB1GABRG2GABRB3
SCHEMBL10054147 0.70 IDO1 (0.33) IDO1SETD7
SCHEMBL22270186 0.70 IDO1 (0.51) GPBAR1HSP90AA1HSP90AB1GABRG2GABRB3
SCHEMBL11705102 0.70 ALDH1A1 (0.54) P2RX4CYP1A2CYP2D6KDM4EMAPK1
SCHEMBL697648 0.69 HSP90AA1 (0.41) HSP90AA1P2RX4GABRG2GABRB3GABRA5
SCHEMBL20829586 0.68 IDO1 (0.41) GPBAR1HSP90AA1HSP90AB1IDO1TDO2
Iodide SCHEMBL698048 0.67 P2RX4 (0.36) P2RX4KDM4EMAPK1ATMMAPT
SCHEMBL22413496 0.65 IDO1 (0.45) GPBAR1HSP90AA1HSP90AB1IDO1TDO2
SCHEMBL23625962 0.65 P2RX4 (0.39) P2RX4KDM4EATMMAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130317212-A1 LIGHT EMITTING MATERIALS FOR ELECTRONICS SOLVAY SA (BE) 2013-11-28 US disclosed
EP-2423214-A1 Light emitting materials for Electronics Solvay SA (BE) 2012-02-29 EP disclosed