SCHEMBL6980489

SCHEMBL6980489

CS(=O)(=O)N1CC(SC(c2ccccc2)(c2ccccc2)c2ccccc2)CC1C(=O)O

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 2/20 0.38
MMP2 P08253 2/20 0.38
MMP9 P14780 1/20 0.38
SLC6A1 P30531 1/20 0.34
SLC6A11 P48066 1/20 0.34
KIF11 P52732 2/20 0.34
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34
CA9 Q16790 1/20 0.34
AGTR2 P50052 3/20 0.33
ACE P12821 1/20 0.33
KMT2A Q03164 1/20 0.33
TSHR P16473 1/20 0.32
HTT P42858 1/20 0.32
POLB P06746 1/20 0.32
APOBEC3A P31941 1/20 0.32
APOBEC3G Q9HC16 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
ECE1 P42892 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5409304 1.00 CA12 (0.38) CA12MMP2MMP9SLC6A1SLC6A11
SCHEMBL7145187 0.88 MMP2 (0.41) CA12MMP2MMP9KMT2A
SCHEMBL7145191 0.88 MMP2 (0.41) CA12MMP2MMP9KMT2A
SCHEMBL5409486 0.88 MMP2 (0.41) CA12MMP2MMP9KMT2A
SCHEMBL5409431 0.84 NPSR1 (0.36) CA12MMP2MMP9KIF11ECE1
SCHEMBL5409437 0.84 NPSR1 (0.36) CA12MMP2MMP9KIF11ECE1
SCHEMBL7135112 0.82 CA12 (0.32) CA12MMP2MMP9KIF11ECE1
SCHEMBL7135113 0.82 CA12 (0.32) CA12MMP2MMP9KIF11ECE1
SCHEMBL7138136 0.81 KIF11 (0.34) CA12MMP2MMP9SLC6A1SLC6A11
SCHEMBL7150563 0.81 KIF11 (0.34) CA12MMP2MMP9SLC6A1SLC6A11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1317428-A1 PYRROLIDINE-2-CARBOXYLIC ACID HYDRAZIDE DERIVATIVES FOR USE AS METALLOPROTEASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2003-06-11 EP disclosed
EP-1303486-A1 PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2003-04-23 EP disclosed
EP-1303485-A1 PYRROLIDINE DERIVATIVES AS INHIBITORS OF ENDOTHELIN-CONVERTING ENZYME F. HOFFMANN-LA ROCHE AG (CH) 2003-04-23 EP disclosed
WO-2002008185-A1 PYRROLIDINE DERIVATIVES AS METALLOPROTEASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2002-01-31 WO disclosed
WO-2002006222-A1 PYRROLIDINE DERIVATIVES AS INHIBITORS OF ENDOTHELIN-CONVERTING ENZYME F. HOFFMANN-LA ROCHE AG (CH) 2002-01-24 WO disclosed
WO-2002006224-A1 PYRROLIDINE-2-CARBOXYLIC ACID HYDRAZIDE DERIVATIVES FOR USE AS METALLOPROTEASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2002-01-24 WO disclosed