Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.67 |
| ▸ | DRD4 | P21917 | 8/20 | 0.67 |
| ▸ | DRD3 | P35462 | 8/20 | 0.67 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | CCR3 | P51677 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NSD2 | O96028 | 1/20 | 0.43 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6975763 | 0.85 | DRD2 (0.86) | DRD2DRD4DRD3ACHEBCHE | |
| SCHEMBL1387890 | 0.81 | DRD4 (1.00) | DRD2DRD4DRD3MEN1KMT2A | |
| SCHEMBL6976152 | 0.80 | HRH4 (0.57) | DRD2DRD4DRD3HRH3HRH4 | |
| SCHEMBL6975639 | 0.80 | MAP3K12 (0.49) | DRD2DRD4DRD3ACHEMEN1 | |
| SCHEMBL6981484 | 0.78 | DRD2 (0.58) | DRD2DRD4DRD3ACHEBCHE | |
| SCHEMBL19716357 | 0.75 | HRH4 (0.56) | DRD2DRD4DRD3HRH4MEN1 | |
| SCHEMBL2930230 | 0.74 | DRD2 (0.72) | DRD2DRD4DRD3ACHEBCHE | |
| SCHEMBL604313 | 0.73 | HRH4 (0.80) | HRH3HRH4 | |
| SCHEMBL604312 | 0.73 | HRH4 (0.80) | HRH3HRH4 | |
| SCHEMBL13490551 | 0.72 | DRD2 (0.52) | DRD2DRD4DRD3ACHEBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892795-B1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMA (JP) | 2003-01-08 | — | — | EP | disclosed |
| US-5948786-A | BLOCKING TUMOR NECROSIS FACTOR | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-09-07 | — | — | US | disclosed |
| EP-0892795-A1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997038992-A1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1997-10-23 | — | — | WO | disclosed |