Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.86 |
| ▸ | DRD4 | P21917 | 9/20 | 0.86 |
| ▸ | DRD3 | P35462 | 9/20 | 0.86 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 3/20 | 0.48 |
| ▸ | BCHE | P06276 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1387890 | 0.93 | DRD4 (1.00) | DRD2DRD4DRD3ALDH1A1 | |
| SCHEMBL6980499 | 0.85 | DRD2 (0.67) | DRD2DRD4DRD3ACHEBCHE | |
| SCHEMBL13490449 | 0.79 | DRD2 (0.59) | DRD2DRD4DRD3ACHEBCHE | |
| SCHEMBL6981484 | 0.78 | DRD2 (0.58) | DRD2DRD4DRD3ACHEBCHE | |
| SCHEMBL6981381 | 0.75 | HRH4 (0.62) | DRD2DRD4DRD3ADORA2AADORA1 | |
| SCHEMBL6969942 | 0.75 | MAP3K12 (0.60) | DRD2DRD4DRD3ADORA2AADORA1 | |
| SCHEMBL2930230 | 0.74 | DRD2 (0.72) | DRD2DRD4DRD3ACHEBCHE | |
| SCHEMBL1388551 | 0.73 | DRD4 (0.70) | DRD2DRD4DRD3 | |
| SCHEMBL13490551 | 0.72 | DRD2 (0.52) | DRD2DRD4DRD3ACHEBCHE | |
| SCHEMBL171620 | 0.72 | HPGDS (0.55) | DRD2DRD4DRD3ACHEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892795-B1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMA (JP) | 2003-01-08 | — | — | EP | disclosed |
| US-5948786-A | BLOCKING TUMOR NECROSIS FACTOR | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-09-07 | — | — | US | disclosed |
| EP-0892795-A1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997038992-A1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1997-10-23 | — | — | WO | disclosed |