Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | GBA1 | P04062 | 1/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.44 |
| ▸ | ACACB | O00763 | 3/20 | 0.42 |
| ▸ | ACACA | Q13085 | 3/20 | 0.42 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6979493 | 1.00 | SIGMAR1 (0.49) | SIGMAR1GBA1TLR7TLR8ACACB | |
| SCHEMBL6979788 | 1.00 | SIGMAR1 (0.49) | SIGMAR1GBA1TLR7TLR8ACACB | |
| SCHEMBL6981163 | 0.82 | PARP1 (0.45) | SIGMAR1 | |
| SCHEMBL6970712 | 0.82 | PARP1 (0.45) | SIGMAR1 | |
| SCHEMBL6977139 | 0.82 | PARP1 (0.45) | SIGMAR1 | |
| SCHEMBL6974607 | 0.78 | NAMPT (0.50) | TLR7 | |
| SCHEMBL6133804 | 0.77 | SIGMAR1 (0.51) | SIGMAR1NR2F2RAB9A | |
| SCHEMBL6133267 | 0.77 | KDM4E (0.53) | SIGMAR1BRD4 | |
| SCHEMBL8395330 | 0.76 | TLR7 (0.40) | SIGMAR1GBA1TLR7TLR8ACACB | |
| SCHEMBL8393078 | 0.76 | TLR7 (0.40) | SIGMAR1GBA1TLR7TLR8ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892795-B1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMA (JP) | 2003-01-08 | — | — | EP | disclosed |