Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 14/20 | 0.45 |
| ▸ | TNKS | O95271 | 12/20 | 0.45 |
| ▸ | PARP2 | Q9UGN5 | 12/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981163 | 1.00 | PARP1 (0.45) | PARP1TNKSPARP2HSP90AA1HSP90AB1 | |
| SCHEMBL6977139 | 1.00 | PARP1 (0.45) | PARP1TNKSPARP2HSP90AA1HSP90AB1 | |
| SCHEMBL6979788 | 0.82 | SIGMAR1 (0.49) | SIGMAR1 | |
| SCHEMBL6980502 | 0.82 | SIGMAR1 (0.49) | SIGMAR1 | |
| SCHEMBL6968387 | 0.79 | ALDH1A1 (0.51) | PARP1HSP90AA1HSP90AB1ALDH1A1HSD17B10 | |
| SCHEMBL6976291 | 0.78 | LMNA (0.55) | HSP90AA1HSP90AB1ALDH1A1HSD17B10HPGD | |
| SCHEMBL6979861 | 0.76 | ROCK1 (0.42) | PARP1TNKSPARP2HSP90AA1HSP90AB1 | |
| SCHEMBL6981315 | 0.76 | MEN1 (0.58) | ALDH1A1 | |
| SCHEMBL6976998 | 0.76 | KDM4E (0.53) | ALDH1A1HSD17B10HPGDKDM4ECASP1 | |
| SCHEMBL6974607 | 0.76 | NAMPT (0.50) | HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892795-B1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMA (JP) | 2003-01-08 | — | — | EP | disclosed |
| EP-0892795-A1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997038992-A1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1997-10-23 | — | — | WO | disclosed |