Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK6 | P43250 | 3/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.64 |
| ▸ | GAA | P10253 | 12/20 | 0.64 |
| ▸ | HPGD | P15428 | 11/20 | 0.64 |
| ▸ | GLA | P06280 | 10/20 | 0.64 |
| ▸ | MAPT | P10636 | 9/20 | 0.64 |
| ▸ | CASP1 | P29466 | 7/20 | 0.64 |
| ▸ | CASP7 | P55210 | 7/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.64 |
| ▸ | SAE1 | Q9UBE0 | 3/20 | 0.64 |
| ▸ | UBA2 | Q9UBT2 | 3/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.57 |
| ▸ | THRB | P10828 | 4/20 | 0.57 |
| ▸ | NSD2 | O96028 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30656632 | 0.82 | GRK6 (1.00) | GRK6KDM4EALDH1A1GAAHPGD | |
| SCHEMBL6981091 | 0.82 | GRK6 (1.00) | GRK6KDM4EALDH1A1GAAHPGD | |
| SCHEMBL14907744 | 0.79 | GRK6 (1.00) | GRK6KDM4EALDH1A1GAAHPGD | |
| SCHEMBL15256916 | 0.79 | KDM4E (0.62) | GRK6KDM4EALDH1A1GAAHPGD | |
| SCHEMBL15256914 | 0.79 | SAE1 (1.00) | GRK6KDM4EALDH1A1GAAHPGD | |
| SCHEMBL8163981 | 0.78 | KDM4E (0.73) | GRK6KDM4EALDH1A1GAAHPGD | |
| SCHEMBL5527836 | 0.78 | TSHR (0.83) | GRK6KDM4EALDH1A1GAAHPGD | |
| SCHEMBL17538610 | 0.78 | TOP2A (0.61) | GRK6KDM4EALDH1A1GAAHPGD | |
| SCHEMBL14907745 | 0.78 | GRK6 (1.00) | GRK6KDM4EALDH1A1GAAHPGD | |
| SCHEMBL18153563 | 0.78 | KDM4E (0.74) | GRK6KDM4EALDH1A1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012064897-A2 | BICYCLIC AND TRICYCLIC INHIBITORS OF SUMOYLATION ENZYMES AND METHODS FOR THEIR USE | CHEN YUAN (US) | 2012-05-18 | — | — | WO | disclosed |