Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 18/20 | 0.74 |
| ▸ | GAA | P10253 | 16/20 | 0.74 |
| ▸ | MAPT | P10636 | 16/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 15/20 | 0.74 |
| ▸ | HPGD | P15428 | 15/20 | 0.74 |
| ▸ | GLA | P06280 | 13/20 | 0.74 |
| ▸ | THRB | P10828 | 6/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.74 |
| ▸ | MEN1 | O00255 | 5/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.74 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.71 |
| ▸ | LMNA | P02545 | 7/20 | 0.69 |
| ▸ | APAF1 | O14727 | 4/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | CASP1 | P29466 | 8/20 | 0.68 |
| ▸ | CASP7 | P55210 | 8/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15032615 | 0.84 | KDM4E (0.61) | KDM4EGAAMAPTALDH1A1HPGD | |
| SCHEMBL14907744 | 0.78 | GRK6 (1.00) | KDM4EGAAMAPTALDH1A1HPGD | |
| SCHEMBL6980640 | 0.78 | GRK6 (0.70) | KDM4EGAAMAPTALDH1A1HPGD | |
| SCHEMBL14907745 | 0.77 | GRK6 (1.00) | KDM4EGAAMAPTALDH1A1HPGD | |
| SCHEMBL15032613 | 0.73 | KDM4E (1.00) | KDM4EGAAMAPTALDH1A1HPGD | |
| SCHEMBL8163981 | 0.73 | KDM4E (0.73) | KDM4EGAAMAPTALDH1A1HPGD | |
| SCHEMBL15256914 | 0.71 | SAE1 (1.00) | KDM4EGAAMAPTALDH1A1HPGD | |
| SCHEMBL6981091 | 0.70 | GRK6 (1.00) | KDM4EGAAMAPTALDH1A1HPGD | |
| SCHEMBL30656632 | 0.70 | GRK6 (1.00) | KDM4EGAAMAPTALDH1A1HPGD | |
| SCHEMBL13991143 | 0.70 | CNR2 (0.67) | KDM4EMAPTALDH1A1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180087086-A1 | CELL EGRESS AND INVASION INHIBITORS AND THEIR USE AS ANTIPARASITICAL AGENTS | THE JOHNS HOPKINS UNIVERSITY | 2018-03-29 | — | — | US | claimed |
| WO-2016168536-A1 | CELL EGRESS AND INVASION INHIBITORS AND THEIR USE AS ANTIPARASITICAL AGENTS | THE JOHNS HOPKINS UNIVERSITY (US) | 2016-10-20 | — | — | WO | claimed |
| US-20180087086-A1 | CELL EGRESS AND INVASION INHIBITORS AND THEIR USE AS ANTIPARASITICAL AGENTS | THE JOHNS HOPKINS UNIVERSITY | 2018-03-29 | — | — | US | disclosed |
| US-20180087086-A1 | CELL EGRESS AND INVASION INHIBITORS AND THEIR USE AS ANTIPARASITICAL AGENTS | THE JOHNS HOPKINS UNIVERSITY | 2018-03-29 | — | — | US | disclosed |
| US-20180087086-A1 | CELL EGRESS AND INVASION INHIBITORS AND THEIR USE AS ANTIPARASITICAL AGENTS | THE JOHNS HOPKINS UNIVERSITY | 2018-03-29 | — | — | US | disclosed |
| WO-2016168536-A1 | CELL EGRESS AND INVASION INHIBITORS AND THEIR USE AS ANTIPARASITICAL AGENTS | THE JOHNS HOPKINS UNIVERSITY (US) | 2016-10-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180087086-A1 | CELL EGRESS AND INVASION INHIBITORS AND THEIR USE AS ANTIPARASITICAL AGENTS | MMP8, MIF, MMP3 | KDM4E 3546/4885GAA 1361/4885MAPT 4278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.