Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR6 | P51684 | 3/20 | 0.51 |
| ▸ | LSS | P48449 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981045 | 0.96 | LSS (0.54) | CCR6LSSMAPTKDM4EALDH1A1 | |
| SCHEMBL6978885 | 0.88 | ALDH1A1 (0.54) | CCR6MAPTKDM4EALDH1A1EPHX2 | |
| SCHEMBL6978502 | 0.86 | LSS (0.52) | CCR6LSSMAPTKDM4ENPC1 | |
| SCHEMBL7085163 | 0.85 | LSS (0.69) | LSSALDH1A1NPC1RAB9ACNR1 | |
| SCHEMBL6970581 | 0.83 | LSS (0.56) | LSSMAPTKDM4EALDH1A1CNR1 | |
| SCHEMBL6977047 | 0.76 | LSS (0.51) | LSSMAPTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL26429307 | 0.75 | ALDH1A1 (0.57) | MAPTKDM4EALDH1A1EPHX2MAPK1 | |
| SCHEMBL6975446 | 0.74 | KDM4E (0.53) | MAPTKDM4EALDH1A1CNR1GAA | |
| SCHEMBL7654951 | 0.72 | LSS (0.72) | LSSMAPTALDH1A1NPC1RAB9A | |
| SCHEMBL6980850 | 0.72 | LSS (0.61) | LSSALDH1A1NPC1RAB9ACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925286-B1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ASTRAZENECA AB (SE) | 2003-01-02 | — | — | EP | disclosed |
| US-6093718-A | AN OXIDO-SQUALENE CYCLASE INHIBITOR, ANTICHOLESTEROL AGENT FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND LOWERING CHOLESTEROL LEVELS IN BLOOD PLASMA; TREATING HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2000-07-25 | — | — | US | disclosed |