SCHEMBL6980795

SCHEMBL6980795

O=C(C=CC1CCN(Cc2ccccc2)CC1)c1nc2ccccc2s1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 3/20 0.56
CCR3 P51677 5/20 0.54
CCR1 P32246 4/20 0.54
LTA4H P09960 5/20 0.53
KCNH2 Q12809 3/20 0.50
NPC1 O15118 2/20 0.49
RAB9A P51151 2/20 0.49
MEN1 O00255 1/20 0.49
KMT2A Q03164 1/20 0.49
CHRM4 P08173 1/20 0.48
HTR1A P08908 2/20 0.48
DRD2 P14416 2/20 0.48
HTR2A P28223 2/20 0.48
SLC6A4 P31645 2/20 0.48
HTR7 P34969 2/20 0.48
SMN1; SMN2 Q16637 2/20 0.47
HPGD P15428 1/20 0.47
SLC6A2 P23975 1/20 0.47
HTR2C P28335 1/20 0.47
HRH1 P35367 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6980792 1.00 HDAC8 (0.56) HDAC8CCR3CCR1LTA4HKCNH2
SCHEMBL6980908 0.83 CCR3 (0.54) HDAC8CCR3CCR1LTA4HKCNH2
SCHEMBL6980913 0.81 CCR3 (0.52) CCR3CCR1LTA4HKCNH2NPC1
SCHEMBL6980905 0.79 LTA4H (0.56) CCR3CCR1LTA4HKCNH2NPC1
SCHEMBL6980910 0.79 LTA4H (0.56) CCR3CCR1LTA4HKCNH2NPC1
SCHEMBL6982653 0.78 BCHE (0.67) HDAC8CCR3CCR1NPC1RAB9A
SCHEMBL6982650 0.78 BCHE (0.67) HDAC8CCR3CCR1NPC1RAB9A
SCHEMBL6979906 0.77 ACHE (0.63) CCR3CCR1LTA4HNPC1RAB9A
SCHEMBL6981210 0.77 MEN1 (0.49) HDAC8CCR3CCR1LTA4HKCNH2
SCHEMBL6981212 0.77 MEN1 (0.49) HDAC8CCR3CCR1LTA4HKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0606248-B1 HETEROARYL AMINES AS NOVEL ACETYL CHOLINESTERASE INHIBITORS EISAI CO LTD (JP) 2003-03-26 EP disclosed
US-6303633-B1 FOR THERAPY AND PROPHYLAXIS OF ALZHEIMER'S DISEASE PFIZER INC 2001-10-16 US disclosed
US-6124321-A Heteroaryl amines as novel acetyl cholinesterase inhibitors PFIZER INC (US) 2000-09-26 US disclosed
US-5965574-A Heteroaryl amines as novel acetylcholinesterase inhibitors CHEN YUHPYNG LIANG (US) 1999-10-12 US disclosed
US-5574046-A Heteroaryl amines as novel acetylcholinesterase inhibitors PFIZER INC. (US) 1996-11-12 US disclosed
EP-0606248-A1 HETEROARYL AMINES AS NOVEL ACETYL CHOLINESTERASE INHIBITORS Eisai Co., Ltd. (JP) 1994-07-20 EP disclosed
WO-1993007140-A1 HETEROARYL AMINES AS NOVEL ACETYL CHOLINESTERASE INHIBITORS PFIZER INC. (US) 1993-04-15 WO disclosed