Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | NOS2 | P35228 | 1/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.58 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.58 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MGLL | Q99685 | 1/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981183 | 0.82 | KDM4E (0.67) | KMT2AMEN1KDM4ETSHRNOS2 | |
| SCHEMBL14198379 | 0.82 | TSHR (0.63) | KMT2AMEN1KDM4ETSHRGAA | |
| SCHEMBL17301744 | 0.80 | KMT2A (0.62) | KMT2AMEN1KDM4ETSHRNOS2 | |
| SCHEMBL17301747 | 0.80 | KMT2A (0.62) | KMT2AMEN1KDM4ETSHRNOS2 | |
| SCHEMBL9699514 | 0.78 | KMT2A (0.70) | KMT2AMEN1KDM4ENOS2CHRM2 | |
| SCHEMBL4255064 | 0.78 | TSHR (0.59) | KMT2AMEN1KDM4ETSHRCHRM2 | |
| SCHEMBL10043041 | 0.77 | KMT2A (1.00) | KMT2AMEN1KDM4ETSHRNOS2 | |
| SCHEMBL7976436 | 0.77 | TSHR (0.58) | KMT2AMEN1KDM4ETSHRNOS2 | |
| SCHEMBL5368555 | 0.76 | KDM4E (0.70) | KMT2AMEN1KDM4ENOS2CHRM2 | |
| SCHEMBL20618720 | 0.76 | TSHR (0.60) | KMT2AMEN1KDM4ETSHRNOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923575-B1 | CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-03-12 | — | — | EP | disclosed |
| US-6172085-B1 | CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-01-09 | — | — | US | disclosed |
| EP-0923575-A1 | CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS | Takeda Chemical Industries, Ltd. (JP) | 1999-06-23 | — | — | EP | disclosed |
| WO-1998008842-A1 | CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-03-05 | — | — | WO | disclosed |