Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.66 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.66 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.66 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.61 |
| ▸ | DRD2 | P14416 | 1/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | NOS2 | P35228 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL546475 | 0.86 | ALDH1A1 (0.54) | KDM4ECHRM2CHRM5CHRM3KMT2A | |
| SCHEMBL8311276 | 0.84 | SOS1 (0.58) | KDM4ECHRM2CHRM5CHRM3DRD2 | |
| SCHEMBL5368555 | 0.82 | KDM4E (0.70) | KDM4ECHRM2CHRM5CHRM3CHRM1 | |
| SCHEMBL6980957 | 0.82 | KMT2A (0.63) | KDM4ECHRM2CHRM5CHRM3CHRM1 | |
| SCHEMBL13930435 | 0.81 | SOS1 (0.52) | KDM4ECHRM2CHRM5CHRM3KMT2A | |
| SCHEMBL9699514 | 0.80 | KMT2A (0.70) | KDM4ECHRM2CHRM5CHRM3CHRM1 | |
| SCHEMBL14198379 | 0.78 | TSHR (0.63) | KDM4EKMT2AMEN1ALDH1A1TSHR | |
| SCHEMBL5368551 | 0.77 | KDM4E (0.62) | KDM4ECHRM2CHRM5CHRM3CHRM1 | |
| SCHEMBL26510682 | 0.77 | SMN1; SMN2 (0.62) | KDM4ECHRM2CHRM5CHRM3CHRM1 | |
| SCHEMBL17301744 | 0.76 | KMT2A (0.62) | KDM4ECHRM2CHRM5CHRM3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923575-B1 | CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-03-12 | — | — | EP | disclosed |
| US-6172085-B1 | CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-01-09 | — | — | US | disclosed |