SCHEMBL6980987

SCHEMBL6980987

COc1ccc2c(c1)OC(CN1CCC(CNC(=O)c3cccnc3N)CC1)CO2

nearest known ligand 0.53

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ADRA2C P18825 7/20 0.48
ADRA2A P08913 6/20 0.48
ADRA2B P18089 6/20 0.48
ADRA1D P25100 2/20 0.48
ADRA1A P35348 2/20 0.48
ADRA1B P35368 2/20 0.48
GAA P10253 1/20 0.46
TSHR P16473 1/20 0.46
HTT P42858 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
MTNR1A P48039 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8381361 1.00 ADRA2C (0.48) ADRA2CADRA2AADRA2BADRA1DADRA1A
SCHEMBL6983083 0.90 ADRA1D (0.50) ADRA2CADRA2AADRA2BADRA1DADRA1A
SCHEMBL8381573 0.90 ADRA1D (0.50) ADRA2CADRA2AADRA2BADRA1DADRA1A
SCHEMBL6985811 0.88 ADRA1D (0.50) ADRA2CADRA2AADRA2BADRA1DADRA1A
SCHEMBL6980022 0.88 ADRA1D (0.50) ADRA2CADRA2AADRA2BADRA1DADRA1A
SCHEMBL6980367 0.88 ADRA1D (0.50) ADRA2CADRA2AADRA2BADRA1DADRA1A
SCHEMBL8382308 0.88 ADRA1D (0.50) ADRA2CADRA2AADRA2BADRA1DADRA1A
SCHEMBL6979456 0.88 ADRA1D (0.50) ADRA2CADRA2AADRA2BADRA1DADRA1A
SCHEMBL6982140 0.88 ADRA1D (0.62) ADRA2CADRA2AADRA2BADRA1DADRA1A
SCHEMBL8385881 0.88 ADRA1D (0.62) ADRA2CADRA2AADRA2BADRA1DADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0839145-B1 HETEROCYCLYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS ABBOTT GMBH & CO KG (DE) 2003-11-05 EP claimed
US-5935973-A AFFINITY FOR 5-HT1A, ALPHA1, ALPHA2 AND/OR D2 RECEPTORS; ANTIDEPRESSANTS, ANXIOLYTIC AGENTS, PSYCHOSES, DYSKINESIAS, PARKINSON'S DISEASE, HYPOTENSIVE AGENTS, TOURETTE'S SYNDROME, OBSESSIVE-COMPULSIVE BEHAVIOUR, PANIC ATTACKS, SOCIAL PHOBIAS KNOLL AKTIENGESELLSCHAFT (DE) 1999-08-10 US claimed
EP-0839145-A1 HETEROCYCLYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS Knoll AG (DE) 1998-05-06 EP claimed
WO-1997003071-A1 HETEROCYCLYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS KNOLL AKTIENGESELLSCHAFT (DE) 1997-01-30 WO claimed
US-5935973-A AFFINITY FOR 5-HT1A, ALPHA1, ALPHA2 AND/OR D2 RECEPTORS; ANTIDEPRESSANTS, ANXIOLYTIC AGENTS, PSYCHOSES, DYSKINESIAS, PARKINSON'S DISEASE, HYPOTENSIVE AGENTS, TOURETTE'S SYNDROME, OBSESSIVE-COMPULSIVE BEHAVIOUR, PANIC ATTACKS, SOCIAL PHOBIAS KNOLL AKTIENGESELLSCHAFT (DE) 1999-08-10 US disclosed
EP-0839145-A1 HETEROCYCLYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS Knoll AG (DE) 1998-05-06 EP disclosed
WO-1997003071-A1 HETEROCYCLYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS KNOLL AKTIENGESELLSCHAFT (DE) 1997-01-30 WO disclosed