Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 8/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 8/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 8/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alcohol SCHEMBL8381334 | 0.80 | ADRA1D (0.56) | ADRA1DADRA1AADRA1BDRD2DRD4 | |
| Alcohol SCHEMBL8547581 | 0.80 | ADRA1D (0.56) | ADRA1DADRA1AADRA1BDRD2DRD4 | |
| SCHEMBL6970869 | 0.75 | ADRA1D (0.54) | ADRA1DADRA1AADRA1BDRD2DRD4 | |
| SCHEMBL6977646 | 0.71 | ADRA1D (0.58) | ADRA1DADRA1AADRA1BDRD2DRD4 | |
| SCHEMBL8096185 | 0.70 | ADRA1D (0.58) | ADRA1DADRA1AADRA1BDRD2DRD4 | |
| SCHEMBL8096179 | 0.70 | ADRA1D (0.58) | ADRA1DADRA1AADRA1BDRD2DRD4 | |
| SCHEMBL6980022 | 0.67 | ADRA1D (0.50) | ADRA1DADRA1AADRA1BDRD2DRD4 | |
| SCHEMBL6985811 | 0.67 | ADRA1D (0.50) | ADRA1DADRA1AADRA1BDRD2DRD4 | |
| SCHEMBL6977805 | 0.67 | ADRA1D (0.50) | ADRA1DADRA1AADRA1BDRD2DRD4 | |
| SCHEMBL8386689 | 0.67 | ADRA1D (0.50) | ADRA1DADRA1AADRA1BDRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839145-B1 | HETEROCYCLYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2003-11-05 | — | — | EP | disclosed |