Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | TP53 | P04637 | 3/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | NPEPPS | P55786 | 2/20 | 0.51 |
| ▸ | CCKBR | P32239 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | PMM2 | O15305 | 1/20 | 0.50 |
| ▸ | MPI | P34949 | 1/20 | 0.50 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981971 | 0.89 | KDM4E (0.58) | GAAKDM4ETP53NPSR1HSP90AA1 | |
| SCHEMBL6976175 | 0.85 | TRPV1 (0.62) | GAAKDM4ETP53HSP90AA1SMN1; SMN2 | |
| SCHEMBL6981508 | 0.82 | KDM4E (0.72) | GAAKDM4ETP53LMNASMN1; SMN2 | |
| SCHEMBL6980347 | 0.80 | KDM4E (1.00) | GAAKDM4ETP53NPSR1HSP90AA1 | |
| SCHEMBL6981446 | 0.79 | KDM4E (0.71) | GAAKDM4ETP53LMNASMN1; SMN2 | |
| SCHEMBL6975203 | 0.79 | KDM4E (0.72) | GAAKDM4ETP53SMN1; SMN2HTT | |
| SCHEMBL10999663 | 0.78 | GSR (0.52) | GAAKDM4EHSP90AA1HTTCYP1A2 | |
| SCHEMBL5534269 | 0.78 | CYP1A2 (0.54) | GAALMNAMAPTMAPK1HTT | |
| SCHEMBL1083272 | 0.77 | MTOR (0.51) | GAALMNAHTTCCKBRCYP1A2 | |
| SCHEMBL6979777 | 0.77 | KDM4E (0.68) | GAAKDM4ETP53LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030199530-A1 | New compounds derived from quinazoline | LES LABORATORIES SERVIER (FR) | 2003-10-23 | — | — | US | disclosed |
| EP-1346992-A1 | Quinazoline derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-09-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030199530-A1 | New compounds derived from quinazoline | NQO2, XDH, DRD1 | GAA 638/4885KDM4E 4217/4885TP53 3198/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.