Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 8/20 | 0.36 |
| ▸ | NOS2 | P35228 | 8/20 | 0.36 |
| ▸ | NOS3 | P29474 | 6/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6980067 | 0.95 | NOS1 (0.37) | NOS1NOS2NOS3 | |
| SCHEMBL7625168 | 0.78 | NOS2 (0.59) | NOS1NOS2NOS3 | |
| SCHEMBL6976829 | 0.77 | KMT2A (0.33) | — | |
| SCHEMBL7618484 | 0.75 | NOS1 (0.61) | NOS1NOS2NOS3 | |
| SCHEMBL7620647 | 0.74 | NOS1 (0.41) | NOS1NOS2NOS3 | |
| SCHEMBL6981794 | 0.74 | NOS1 (0.33) | NOS1NOS2NOS3 | |
| SCHEMBL8392910 | 0.71 | — | — | |
| SCHEMBL6977501 | 0.70 | NOS1 (0.54) | NOS1NOS2NOS3 | |
| SCHEMBL7621413 | 0.69 | NOS2 (0.58) | NOS1NOS2NOS3 | |
| SCHEMBL6978890 | 0.69 | NOS1 (0.37) | NOS1NOS2NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821674-B1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2003-08-06 | — | — | EP | disclosed |
| US-6043261-A | TREATMENT OF INFLAMMATORY CONDITIONS AFFECTING THE JOINTS, FOR EXAMPLE ARTHRITIS, INFLAMMATORY BOWEL DISEASE, CARDIOVASCULAR ISCHEMIA, DIABETES, HYPERALGESIA, CEREBRAL ISCHEMIA, THROMBOTIC STROKE, GLOBAL ISCHEMIA, NERVOUS SYSTEM DISORDERS | G. D. SEARLE & CO. (US) | 2000-03-28 | — | — | US | disclosed |
| US-6011028-A | Cyclic amidino agents useful as nitric oxide synthase inhibitors | G.D. SEARLE & CO. (US) | 2000-01-04 | — | — | US | disclosed |
| US-5883251-A | ENZYME INHIBITORS | G. D. SEARLE & CO. (US) | 1999-03-16 | — | — | US | disclosed |
| WO-1996033175-A1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-10-24 | — | — | WO | disclosed |