Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.46 |
| ▸ | CDK1 | P06493 | 5/20 | 0.44 |
| ▸ | KDR | P35968 | 4/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 4/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6976469 | 0.79 | SYK (0.49) | KDRAURKAKCNH2SCN9ANPC1 | |
| SCHEMBL6978041 | 0.78 | SYK (0.48) | KDRAURKAKCNH2SCN9ANPC1 | |
| SCHEMBL17260994 | 0.76 | ROCK1 (0.49) | KDRAURKAKCNH2SCN9ANPC1 | |
| SCHEMBL5263722 | 0.76 | PIK3CA (0.48) | CDK1KDRAGPAT2AURKAKCNH2 | |
| SCHEMBL5394104 | 0.76 | EPHB4 (0.45) | CDK1AURKAKCNH2SCN9ANPC1 | |
| SCHEMBL5443900 | 0.76 | SCN9A (0.51) | CDK1AURKAKCNH2SCN9ANPC1 | |
| SCHEMBL3302653 | 0.76 | LMNA (0.67) | CDK1KDRAURKAKCNH2SCN9A | |
| SCHEMBL3988183 | 0.75 | AURKA (0.65) | CDK1AURKANPC1MAPTMAPK1 | |
| SCHEMBL4767203 | 0.75 | NPC1 (0.46) | CDK1AURKAKCNH2SCN9ANPC1 | |
| SCHEMBL18921584 | 0.74 | ACHE (0.54) | CDK2CCNE1ROCK1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862560-B1 | SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2003-04-02 | — | — | EP | disclosed |
| US-6235746-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATIVE AGENT | CELLTECH THERAPEUTICS, LIMITED (GB) | 2001-05-22 | — | — | US | disclosed |
| US-5958935-A | Substituted 2-anilinopyrimidines useful as protein kinase inhibitors | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-09-28 | — | — | US | disclosed |